Design and development of controlled porosity osmotic tablet of diltiazem hydrochloride
نویسندگان
چکیده
منابع مشابه
Development and evaluation of microporous osmotic tablets of diltiazem hydrochloride
Microporous osmotic tablet of diltiazem hydrochloride was developed for colon targeting. These prepared microporous osmotic pump tablet did not require laser drilling to deliver the drug to the specific site of action. The tablets were prepared by wet granulation method. The prepared tablets were coated with microporous semipermeable membrane and enteric polymer using conventional pan coating p...
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Aim: The objective of this study was to identify critical formulation parameters affecting the drug release from controlled porosity osmotic tablet of milnacipran hydrochloride employing the concept of design of experiments. Materials and Methods: The optimized amount of ethocel (X1) and mannitol (X2) in core and percentage of sorbitol (X3) in coat were determined employing a three-factor, thre...
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The purpose of this study was to design and optimize an oral controlled release acyclovir mucoadhesive tablet, in term of its drug release and mucoadhesive strength. A 32 full factorial design was employed to study the effect of independent variables like Carbopol-934P and hydroxypropyl methylcellulose K100M, which significantly influence characteristics like swelling index, ex-vivo mucoadhesiv...
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The purpose of this study was to design and optimize an oral controlled release acyclovir mucoadhesive tablet, in term of its drug release and mucoadhesive strength. A 32 full factorial design was employed to study the effect of independent variables like Carbopol-934P and hydroxypropyl methylcellulose K100M, which significantly influence characteristics like swelling index, ex-vivo mucoadhesiv...
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Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...
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ژورنال
عنوان ژورنال: Journal of Advanced Pharmaceutical Technology & Research
سال: 2012
ISSN: 2231-4040
DOI: 10.4103/2231-4040.104714